Vascular Research Division, Center for Excellence in Vascular Biology, BWH   Brigham and Women's Hospital, a teaching hospital affiliated with Harvard Medical School
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Core Facilities
Morphology Core


Primary Goal

The primary goal of the Morphology Core is to make available to the investigators of the Vascular Research Division the expertise, facilities, techniques and technical support required for morphologic, immunolocalization and RNA in situ hybridization studies of cultured cells and of animal and human tissues at both the light and electron microscopic level. Additionally, Dr. Milstone and Mr. Stavrakis provide consultation to investigators within the Division in interpreting histopathologic changes and in procedures for selecting and preparing tissues from experimental animals for morphologic studies.


  • Specimen preparation
  • Histopathology
  • Immunohistochemistry of microscopic sections
  • Immunohistochemistry of whole mount specimens
  • In situ hybridization
  • Electron microscopy
  • Immunoelectron microscopy


The Morphology Core laboratory is located on the seventh floor of Harvard's New Research Building (HNRB), within the Center for Excellence in Vascular Biology's Vascular Research Division of Brigham & Women's Hospital. Equipment is available within the Core laboratory, the Vascular Research Division and the Department of Pathology for processing tissues and cultured cells for light microscopy, immunohistochemistry (frozen sections and paraffin embedded and sections), electron microscopy and immunoelectron microscopy, embedding in paraffin, photomicroscopy, scanning and transmission electron microscopy, radioisotopic and non-radioactive in situ hybridization, and image analysis hardware, software and consultant expertise.


Other members of the Department of Pathology serve as consultants to this Core. Dr. Helmut Rennke is highly experienced in electron microscopy and immunohistochemistry and Dr. Daniel Friend is an internationally recognized microscopist and cell biologist with particular expertise in immuno-light and electron microscopy. Dr. Friend also directs a Morphology Core Facility in the Department of Rheumatology and Immunology at Brigham and Women's Hospital (Dr. Frank Austen, Chairman).


Click here for Morphology Core selected references.


Core Facilities



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